myocardial capillary density in normal and diabetic male rats: effect of bezafibrate
نویسندگان
چکیده
cardiovascular disease is the common cause of mortality in diabetic subjects. recently, it is indicated that peroxisome proliferator-activated receptors (ppars) agonists have beneficial effect on cardiovascular system especially on angiogenesis. ppars have three isotypes: pparα, pparβ/δ and pparγ. in this study, we evaluated the effect of bezafibrate as pan ppar agonist on myocardial capillary density in type i diabetic rats. eighteen male wistar rats were randomly divided into three groups (n=6 each): control, diabetic and diabetic+bezafibrate (400 mg/kg/day) by gavage every day. diabetes was induced by a single dose of streptozotocin (55 mg/kg), intraperitoneally. after 21 days, capillary density in the myocardial tissue was evaluated by immunohistochemical staining and reported as capillaries per mm 2 . blood samples were taken before and after the experiment. diabetes was associated by lower serum nitric oxide (no) concentration and reduced myocardial capillary density compared to control group (121.71 ± 13.32 vs. 158.78 ± 11.08 /mm 2 ; p <0.05). administration of bezafibrate significantly increased serum no level and improved angiogenesis in myocardial tissue of diabetic animals (170.24 ± 15.76 vs.121.71 ± 13.32 /mm 2 ; p <0.05). there was a positive correlation between serum no concentration and myocardial capillary density (r=0.90). activation of all isotypes of ppar by bezafibrate improves heart capillary density in diabetic animals and it seems that it can be considered for treatment or prevention of coronary heart disease in diabetic subjects.
منابع مشابه
Myocardial capillary density in normal and diabetic male rats: Effect of bezafibrate
Cardiovascular disease is the common cause of mortality in diabetic subjects. Recently, it is indicated that peroxisome proliferator-activated receptors (PPARs) agonists have beneficial effect on cardiovascular system especially on angiogenesis. PPARs have three isotypes: PPARα, PPARβ/δ and PPARγ. In this study, we evaluated the effect of bezafibrate as pan PPAR agonist on myocardial capillary ...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولThe effect of eight weeks of moderate-intensity endurance training on myocardial capillary density, ejection fraction and left ventricular shortening fraction in male rats with myocardial infarction
Background and objective: Vascular obstruction and impaired blood flow and oxygen delivery cause a myocardial infarction and limit a personchr('39')s function. Therefore, finding a way to create new arteries and replace blocked arteries has always been of interest to researchers, including exercise physiologists. Therefore, this study was conducted to evaluate the effect of eight weeks of moder...
متن کاملeffects of diabetes on myocardial capillary density and serum biomarkers of angiogenesis in male rats
متن کامل
study the effects of low level laser diode on no production and healing of diabetic and cortisone acetate and normal wounded sd rats
nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...
15 صفحه اولEffects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats
INTRODUCTION Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors. METHODS Twelve male rats were divided into two group...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۸، شماره ۲، صفحات ۱۱۹-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023